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GM(1 4

医院中子照射器I型堆 4

2型糖尿病 3

1)模型 2

MCNP 2

中子通量密度 2

代谢 2

医院中子照射器 2

新型 2

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(GaxIn1−x)2O3薄膜；带隙可调谐；磁控溅射 1

1 1

1) 1

1)幂模型 1

1860 MPa等级 1

1T/2H-MoS2 1

2R-1C模型；嵌入式系统；参数估计；非迭代方法；二次型 1

4250 m 1

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Immunological and virological characteristics of human immunodeficiency virus type 1 superinfection:

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《医学前沿（英文）》 2017年 第11卷 第4期   页码 480-489 doi: 10.1007/s11684-017-0594-8

摘要：

Superinfection is frequently detected among individuals infected by human immunodeficiency virus type I (HIV-1). Superinfection occurs at similar frequencies at acute and chronic infection stages but less frequently than primary infection. This observation indicates that the immune responses elicited by natural HIV-1 infection may play a role in curb of superinfection; however, these responses are not sufficiently strong to completely prevent superinfection. Thus, a successful HIV-1 vaccine likely needs to induce more potent and broader immune responses than those elicited by primary infection. On the other hand, potent and broad neutralization responses are more often detected after superinfection than during monoinfection. This suggests that broadly neutralizing antibodies are more likely induced by sequential immunization of multiple different immunogens than with only one form of envelope glycoprotein immunogens. Understanding why the protection from superinfection by immunity induced by primary infection is insufficient and if superinfection can lead to cross-reactive immune responses will be highly informative for HIV-1 vaccine design.

关键词： human immunodeficiency virus type I     superinfection     incidence     immune response    

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Case report of neurofibromatosis type 1 combined with primary ciliary dyskinesia

《医学前沿（英文）》 2021年 第15卷 第6期   页码 933-937 doi: 10.1007/s11684-021-0860-7

摘要： Neurofibromatosis (NF) is a genetic disease in which the lungs are rarely involved. However, in NF cases with lung involvement, chest computed tomography may show bilateral basal reticulations, apical bullae, and cysts without bronchiectasis. Herein, we report a patient diagnosed with NF on the basis of the results of genetic testing who presented with early-onset wet cough and bronchiectasis. Considering the differential diagnosis of bronchiectasis combined with his early-onset wet cough, sinusitis, and sperm quality decline, we considered the possibility of primary ciliary dyskinesia (PCD). Further electron microscopy analysis of cilia and identification of homozygous mutations in the RSPH4A gene confirmed the diagnosis of PCD. Therefore, for patients with NF, when an image change exists in the lungs that does not correspond to NF, the possibility of other diagnoses, including PCD, must be considered.

关键词： primary ciliary dyskinesia     neurofibromatosis     bronchiectasis     transmission electron microscopy     genetic sequencing    

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Properties of La1-xCexCoO3 system perovskite-type catalysts for diesel engine exhaust removal

GONG Cairong, FAN Guoliang, HOU Yanfeng, ZHANG Zhongrong, SONG Chonglin, HUANG Qifei

《化学科学与工程前沿（英文）》 2007年 第1卷 第1期   页码 6-10 doi: 10.1007/s11705-007-0002-z

摘要： A series of complex oxide LaCeCoO catalysts was synthesized at a low temperature through a combustion process, in which x is among 0, 0.1, 0.2, 0.4 and 0.6 corresponding to the quantity of La partial substitution by Ce. The catalysts were characterized for phase composition using chemical analysis and X-ray diffraction. The catalytic activity of the catalysts in removal of NO, total hydrocarbon (THC) and particulate matter (PM) from diesel exhaust gases were examined in detail using temperature-programmed reaction technique. The results show that after partial substitution of La with Ce, the oxygen vacancy concentration increases significantly and a Co-Co system is formed. Consequently, the catalytic activity in the removal of THC and NO is significantly improved. But for the PM, the effect is not so obvious. The possible catalytic mechanism for this was presented. It is also worth noting that the doped catalysts showed good stability.

关键词： catalytic mechanism     combustion     corresponding     LaCeCoO     catalytic activity    

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Influence of β-elemene on the secretion of angiotensin II and expression of AT1R in hepatic stellate

Ling YANG, Rui ZHU, Qingjing ZHU, Dan DAN, Jin YE, Keshu XU, Xiaohua HOU

《医学前沿（英文）》 2009年 第3卷 第1期   页码 36-40 doi: 10.1007/s11684-009-0020-y

摘要： This study aims to investigate the influence of β-elemene on the secretion of angiotensin II (ANG II) and the expression of angiotensin receptor type 1 (AT1R) in hepatic stellate cells (HSCs). , HSC-T6 were cultured for 24 hours and then treated with different doses of β-elemene (2.5, 5 and 10 mg/L). A control group was also set up. The secretion of ANG II in the supernatant was detected by radioimmunoassay. The mRNA expression of AT1R at 4, 12 and 24 h after treatment was detected by reverse transcription-polymerase chain reaction (RT-PCR), respectively. The protein expression of AT1R was detected by western blot. At the 4th h, the ANG II secretion in the supernatant was significantly inhibited by 10 mg/L β-elemene compared with the control group ( <0.05), while 5.0 mg/L and 2.5 mg/L β-elemene had no inhibitory effect on the secretion of ANG II ( >0.05). At the time point of the 12th h, the secretion of ANG II in the supernatant treated with 10 mg/L and 5.0 mg/L β-elemene was significantly lower than the control ( <0.01, <0.05). Following the treatment with 5.0 mg/L and 2.5 mg/L β-elemene for 24 h, significant inhibition of ANG II secretion was observed ( <0.05), but 10 mg/L β-elemene had no such effect. β-elemene significantly reduced the amount of AT1R mRNA in HSCs after the treatment for 4, 12, and 24 h in a dose-dependent manner. The expression of AT1R protein also decreased after the treatment with β-elemene for 24 h. β-elemene can inhibit the secretion of ANG II and the gene and protein expression of AT1R, which may be the mechanism by which β-elemene prevents the progress of hepatic fibrosis.

关键词： liver cirrhosis     beta-elemene     hepatic stellate cells     angiotensin II     receptor     angiotensin     type 1    

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New practice in semaglutide on type-2 diabetes and obesity: clinical evidence and expectation

《医学前沿（英文）》 2022年 第16卷 第1期   页码 17-24 doi: 10.1007/s11684-021-0873-2

摘要： Obesity is an important risk factor of type 2 diabetes (T2D), which has become an important factor threatening human health. However, no perfect drug choice for obesity exists. Semaglutide is a kind of human glucagon-like peptide-1 (GLP-1) analog that promotes insulin secretion while inhibiting glucagon secretion through a glucose concentration-dependent mechanism. GLP-1 can also delay stomach emptying and suppress appetite to help lose weight. This review summarizes clinical evidence of the semaglutide effect on T2D and obesity and establishes expectations on future clinical trials for obesity treatment.

关键词： semaglutide     type 2 diabetes     obesity    

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Molecular network-based intervention brings us closer to ending the HIV pandemic

Xiaoxu Han, Bin Zhao, Minghui An, Ping Zhong, Hong Shang

《医学前沿（英文）》 2020年 第14卷 第2期   页码 136-148 doi: 10.1007/s11684-020-0756-y

摘要： Precise identification of HIV transmission among populations is a key step in public health responses. However, the HIV transmission network is usually difficult to determine. HIV molecular networks can be determined by phylogenetic approach, genetic distance-based approach, and a combination of both approaches. These approaches are increasingly used to identify transmission networks among populations, reconstruct the history of HIV spread, monitor the dynamics of HIV transmission, guide targeted intervention on key subpopulations, and assess the effects of interventions. Simulation and retrospective studies have demonstrated that these molecular network-based interventions are more cost-effective than random or traditional interventions. However, we still need to address several challenges to improve the practice of molecular network-guided targeting interventions to finally end the HIV epidemic. The data remain limited or difficult to obtain, and more automatic real-time tools are required. In addition, molecular and social networks must be combined, and technical parameters and ethnic issues warrant further studies.

关键词： human immunodeficiency virus type 1     molecular cluster     transmission cluster     risk network     targeted intervention     evaluation    

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Personalized medicine of type 2 diabetes

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《医学前沿（英文）》 2013年 第7卷 第1期   页码 1-3 doi: 10.1007/s11684-013-0241-y

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Metabolomics in human type 2 diabetes research

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《医学前沿（英文）》 2013年 第7卷 第1期   页码 4-13 doi: 10.1007/s11684-013-0248-4

摘要：

The high prevalence of diabetes and diabetic complications has caused a huge burden on the modern society. Although scientific advances have led to effective strategies for preventing and treating diabetes over the past several decades, little progress has been made toward curing the disease or even getting it under control, from a public health and overall societal standpoint. There is still a lack of reliable biomarkers indicative of metabolic alterations associated with diabetes and different drug responses, highlighting the need for the development of early diagnostic and prognostic markers for diabetes and diabetic complications. The emergence of metabolomics has allowed researchers to systemically measure the small molecule metabolites, which are sensitive to the changes of both environmental and genetic factors and therefore, could be regarded as the link between genotypes and phenotypes. During the last decade, the progression made in metabolomics has provided insightful information on disease development and disease onset prediction. Recent studies using metabolomics approach coupled with statistical tools to predict incident diabetes revealed a number of metabolites that are significantly altered, including branched-chain and aromatic amino acids, such as isoleucine, leucine, valine, tyrosine and phenylalanine, as diagnostic or highly-significant predictors of future diabetes. This review summarizes the current findings of metabolomic studies in human investigations with the most common form of diabetes, type 2 diabetes.

关键词： metabolomics     type 2 diabetes     metabolic pathway     mass spectrometry     nuclear magnetic resonance (NMR)    

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Correction to: Effect of wood dust type on mechanical properties, wear behavior, biodegradability, and

《结构与土木工程前沿（英文）》 2021年 第15卷 第4期   页码 1071-1071 doi: 10.1007/s11709-021-0736-6

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执行器饱和条件下不确定的中立型分数阶时滞系统的稳定性分析 Research Articles

Zahra Sadat AGHAYAN1,Alireza ALFI1,J. A. TENREIRO MACHADO2

《信息与电子工程前沿（英文）》 2021年 第22卷 第10期   页码 1402-1412 doi: 10.1631/FITEE.2000438

摘要： 分析了执行器饱和条件下中立型分数阶时滞系统的鲁棒稳定性问题。构建了一个Lyapunov-Krasovskii （LK）函数，并给出此类系统的渐近鲁棒稳定性条件，这些条件使用Lyapunov直接方法构造的线性矩阵不等式（LMIs）表示。引入一种算法计算状态反馈控制器的增益以扩展吸引域。数值示例验证了理论结果。

关键词： 分数阶系统；稳定性；中立时滞；鲁棒性；饱和性    

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The mechanisms linking adiposopathy to type 2 diabetes

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《医学前沿（英文）》 2013年 第7卷 第4期   页码 433-444 doi: 10.1007/s11684-013-0288-9

摘要：

Obesity is defined as excessive accumulation of body fat in proportion to body size. When obesity occurs, the functions of adipose tissue may be deregulated, which is termed as adiposopathy. Adiposopathy is an independent risk factor for many diseases, including diabetes and cardiovascular diseases. In overweight or obese subjects with adiposopathy, hyperlipidemia exerts lipotoxicity in pancreatic islet and liver and induces pancreatic β cell dysfunction and liver insulin resistance, which are the decisive factors causing type 2 diabetes. Moreover, adipokines have been shown to play important roles in the regulation of glucose homeostasis. When adiposopathy occurs, abnormal changes in the serum adipokine profile correlate with the development and progression of pancreatic β cell dysfunction and insulin resistance in peripheral tissue. The current paper briefly discusses the latest findings regarding the effects of adiposopathy-related lipotoxicity and cytokine toxicity on the development of type 2 diabetes.

关键词： obesity     adiposopathy     lipotoxicity     adipokines     diabetes    

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Mechanical performance analysis and stiffness test of a new type of suspension bridge

《结构与土木工程前沿（英文）》 2021年 第15卷 第5期   页码 1160-1180 doi: 10.1007/s11709-021-0760-6

摘要： A new type of suspension bridge is proposed based on the gravity stiffness principle. Compared with a conventional suspension bridge, the proposed bridge adds rigid webs and cross braces. The rigid webs connect the main cable and main girder to form a truss that can improve the bending stiffness of the bridge. The cross braces connect the main cables to form a closed space truss structure that can improve the torsional stiffness of the bridge. The rigid webs and cross braces are installed after the construction of a conventional suspension bridge is completed to resist different loads with different structural forms. A new type of railway suspension bridge with a span of 340 m and a highway suspension bridge with a span of 1020 m were designed and analysed using the finite element method. The stress, deflection of the girders, unbalanced forces of the main towers, and natural frequencies were compared with those of conventional suspension bridges. A stiffness test was carried out on the new type of suspension bridge with a small span, and the results were compared with those for a conventional bridge. The results showed that the new suspension bridge had a better performance than the conventional suspension bridge.

关键词： new type of suspension bridge     stiffness test     mechanical performance     railway bridge     space truss    

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Targeted therapy of desmoid-type fibromatosis: mechanism, current situation, and future prospects

Zhen Wang, Jianhui Wu, Xiuyun Tian, Chunyi Hao

《医学前沿（英文）》 2019年 第13卷 第4期   页码 427-437 doi: 10.1007/s11684-018-0672-6

摘要： Desmoid-type fibromatosis (DF) is a rare monoclonal fibroblastic proliferation that is characterized by locally infiltrative but rarely metastatic lesions. Tyrosine kinase and γ-secretase inhibitors are primarily used in the targeted therapy of DF. The use of these drugs, however, is mainly based on the recommendations of retrospective studies with small sample sizes. Previous studies that focused on the mechanism, efficacy, and safety of targeted therapy for DF were reviewed to provide references for clinical applications and research. The efficacy and safety of targeted therapy were compared with those of other systemic therapy options. Targeted therapy does not provide considerable advantages in efficacy and safety over other medical treatments and is usually applied after the failure of antihormonal therapies, nonsteroidal anti-inflammatory drugs, and chemotherapy. Further studies are required to explore the mechanism, indications, and appropriate drug dosage of the targeted therapy of DF.

关键词： targeted therapy     desmoid-type fibromatosis     tyrosine kinase inhibitor     γ-secretase inhibitor    

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Development of an axial-type fan with an optimization method

Chong-hyun CHO, Soo-yong CHO, Chaesil KIM,

《能源前沿（英文）》 2009年 第3卷 第4期   页码 414-422 doi: 10.1007/s11708-009-0038-5

摘要： An axial-type fan that operates at a relative total pressure of 671Pa and a static pressure of 560Pa with a flowrate of 416.6m/min is developed using an optimization technique based on the gradient method. Prior to the optimization of the fan blade, a three-dimensional axial-type fan blade is designed based on the free-vortex method along the radial direction. Twelve design variables are applied to the optimization of the rotor blade, and one design variable is selected for optimizing a stator which is located behind the rotor to support a fan-driving motor. The total and static pressure are applied to the restriction condition with the operating flowrate on the design point, and the efficiency is chosen as the response variable to be maximized. Through these procedures, an initial axial-fan blade designed by the free vortex method is modified to increase the efficiency with a satisfactory operating condition. The optimized fan is tested and compared with the performance obtained with the same class fan to figure out the optimization effect. The test results show that the optimized fan not only satisfies the restriction conditions but also operates at the same efficiency even though the tip clearance of the optimized fan is greater than 30%. The experimental and numerical tests show that this optimization method can improve the efficiency and operating pressures on axial-type fans.

关键词： axial-type fan     gradient method     free-vortex method     design variable     total pressure     static pressure     operating flowrate    

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Low-temperature CO oxidation over Au-doped 13X-type zeolite catalysts: preparation and catalytic activity

Qing YE, Donghui LI, Jun ZHAO, Jiansheng ZHAO, Tianfang KANG, Shuiyuan CHENG

《环境科学与工程前沿（英文）》 2011年 第5卷 第4期   页码 497-504 doi: 10.1007/s11783-011-0256-z

摘要： Au-supported 13X-type zeolite (Au/13X) was synthesized using a common deposition–precipitation (DP) method with a solution of sodium carbonate as a precipitate agent. Further testing was conducted to test for catalytic oxidation of CO. A study was conducted on the effects of different preparation conditions (i.e., chloroauric acid concentration, solution temperature, pH of solution, and calcinations temperature) on Au/13X for CO oxidation. In respect to the catalytic activity, the relationship between different the preparation conditions and gold particles in 13X zeolite was analyzed using X-ray diffraction, TEM and XPS. The activity of Au/13X catalysts in CO oxidation was dependent on the chloroauric acid concentration. From XRD results, a higher chloroauric acid concentration induced larger gold nanoparticles, which resulted in lower catalytic activity. Results revealed that higher temperatures induced higher Au loading, homogeneous deposit, and smaller gold clusters on the support of 13X, resulting in higher CO activity. Furthermore, a pH of 5 or 6 generated greater amounts of Au loading and smaller Au particles on 13X than at a pH of 8 or 9. This may be a result of an effective exchange between and Au(OH) Cl on specific surface sites of zeolite under the pH’s 5 and 6. The sample calcined at 300°C showed the highest activity, which may be due to the sample’s calcined at 200°C inability to decompose completely to metallic gold while the sample calcined at 400°C had larger particles of gold deposited on the support. It can be concluded from this study that Au/13X prepared from a gold solution with an initial chloroauric acid solution concentration of 1.5 × 10 mol·L gold solution pH of 6, solution temperature of around 90°C, and a calcination temperature of 300°C provides optimum catalytic activity for CO oxidation.

关键词： 13X-type zeolite     CO oxidation     gold solution     pH     calcination temperature    

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标题 作者 时间 类型 操作

Immunological and virological characteristics of human immunodeficiency virus type 1 superinfection:

null

期刊论文

Case report of neurofibromatosis type 1 combined with primary ciliary dyskinesia

期刊论文

Properties of La1-xCexCoO3 system perovskite-type catalysts for diesel engine exhaust removal

GONG Cairong, FAN Guoliang, HOU Yanfeng, ZHANG Zhongrong, SONG Chonglin, HUANG Qifei

期刊论文

Influence of β-elemene on the secretion of angiotensin II and expression of AT1R in hepatic stellate

Ling YANG, Rui ZHU, Qingjing ZHU, Dan DAN, Jin YE, Keshu XU, Xiaohua HOU

期刊论文

New practice in semaglutide on type-2 diabetes and obesity: clinical evidence and expectation

期刊论文

Molecular network-based intervention brings us closer to ending the HIV pandemic

Xiaoxu Han, Bin Zhao, Minghui An, Ping Zhong, Hong Shang

期刊论文

Personalized medicine of type 2 diabetes

null

期刊论文

Metabolomics in human type 2 diabetes research

null

期刊论文

Correction to: Effect of wood dust type on mechanical properties, wear behavior, biodegradability, and

期刊论文

执行器饱和条件下不确定的中立型分数阶时滞系统的稳定性分析

Zahra Sadat AGHAYAN1,Alireza ALFI1,J. A. TENREIRO MACHADO2

期刊论文

The mechanisms linking adiposopathy to type 2 diabetes

null

期刊论文

Mechanical performance analysis and stiffness test of a new type of suspension bridge

期刊论文

Targeted therapy of desmoid-type fibromatosis: mechanism, current situation, and future prospects

Zhen Wang, Jianhui Wu, Xiuyun Tian, Chunyi Hao

期刊论文

Development of an axial-type fan with an optimization method

Chong-hyun CHO, Soo-yong CHO, Chaesil KIM,

期刊论文

Low-temperature CO oxidation over Au-doped 13X-type zeolite catalysts: preparation and catalytic activity

Qing YE, Donghui LI, Jun ZHAO, Jiansheng ZHAO, Tianfang KANG, Shuiyuan CHENG

期刊论文